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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
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Yes, with modifications
3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes
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