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Work from Marko et al demonstrated that treatment of human neuronal cells with post-exercise serum, albeit aerobic, was associated with decreased expression of amyloid processing enzyme -secretase linked to production of A and increased expression of non-amyloidogenic enzyme -secretase, producing the soluble amyloid proteins that have not been implicated in neurodegeneration (Marko et al., 2022)

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MOTS-c occupies a specific niche: AMPK-driven metabolic enhancement with muscle preservation