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Description

The risk of AD significantly increases with age, particularly after 65 years old [5]

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However, metformin can cross the placenta into the fetus, which has raised concerns about its safety and potential adverse effects

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Lightheadedness is not a direct pharmacological effect listed in FDA labeling but occurs indirectly through hypoglycemia (especially with insulin or sulfonylureas), dehydration from gastrointestinal side effects, or orthostatic hypotension related to weight loss and metabolic changes

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This single substitution extends the peptide survival time from minutes to hours

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