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In hepatocellular carcinoma models induced by DEN combined with either high-fat/high-carbohydrate or low-fat/low-carbohydrate diets, lean m/db mice, and MCD- or CDE-induced liver injuryas well as in human models, exenatide activation of the GLP-1RcAMPPKAEGFRSTAT3 pathway suppressed oncogenic signaling, limited tumor cell growth, and enhanced apoptosis, resulting in a marked reduction in tumor progression (Zhou et al., 2017)
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Blocking the APE1-mediated repair of AP sites leads to cell death, and it is an actively investigated approach for treating cancers
Neuroprotective effects of some nutraceuticals against manganese-induced Parkinsons disease in rats: possible modulatory effects on TLR4/NLRP3/NF-B, GSK-3, Nrf2/HO-1, and apoptotic pathways
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