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Highly palatable food during adolescence improves anxiety-like behaviors and hypothalamic-pituitary-adrenal axis dysfunction in rats that experienced neonatal maternal separation
doi: 10.1136/GUTJNL-2011-301857
To counteract this and make the drug effective for a longer time, inhibitor molecules like that in PDB entry 3gss can be administered along with the drug to inhibit the action of the enzymes
Evidence is weaker than minoxidil / finasteride , so we always use it as an add-on , not a replacement
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