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It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption

Researchers have found that a diet with excess sugar, refined grains, and saturated fats may contribute to increased cortisol levels and in turn, high cortisol levels may be responsible for increased intake of fatty and sugary food

Primarily characterized by progressive degradation of articular cartilage, subchondral bone sclerosis, synovial inflammation, and weakened periarticular muscle strength (1), OA poses a substantial socioeconomic burden, with direct and indirect healthcare costs estimated at approximately 12.5% of the gross domestic product (GDP) in developed countries (2)

As a nutritional therapist, I am frequently asked about the efficacy of GLP-1 for binge eating , specifically how these medications interact with the neurodivergent brain to stop the cycle of restriction and reward