Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, et al
The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE/ mouse model
For example, the STEP 1 trial of once-weekly semaglutide (2.4 mg) in people without diabetes achieved a ~15% average body weight reduction over 68 weeks (source), with a mean baseline BMI of ~38 (source)
Our Approach: Preserving Muscle While Losing Weight At NY Medical Weight Loss, we recommend strategies to protect muscle mass while losing weight: Prioritize Protein: To preserve muscle, we recommend 1.2 to 2.0 grams of protein per kilogram of body weight daily, tailored to your needs and activity level