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Tirzepatide , the dual GIP/GLP-1 receptor agonist, has demonstrated mean heart rate increases of approximately 2-4 beats per minute in the SURPASS clinical trial program, as reflected in the Mounjaro and Zepbound prescribing information

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The majority of these are cardio-protective, including lowering systolic and diastolic blood pressure [5, 6] and attenuating hypotension induced by intraduodenal glucose infusion [7], lowering plasma cholesterol level [5, 8] and ischemiareperfusion injury [9], and delaying the progression of atherosclerotic disease [9]

The mechanisms might involve neuroprotection, reduced inflammation, and improved energy metabolism in the brain