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In contrast, its use in specific clinical contextssuch as circadian rhythm sleep disorders, neurodegenerative diseases, or metabolic dysregulationis addressed as an adjunctive therapeutic approach, where evidence remains heterogeneous and often limited to small-scale or short-term studies

Research has suggested BPC-157 may counteract effects of both L-NAME (NO synthase inhibition) and L-arginine (NO substrate overload) behaving as a *balancer* of NO signalling rather than a one-directional agonist or antagonist

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Curr Opin Neurobiol 81:102733 Hasegawa E, Miyasaka A, Sakurai K et al (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice