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Hypoxia-induced mROS inhibits HIF-1 hydroxylation and upregulates the HIF-1/PDK1&PDK2/p-PDH-E1 axis, enhancing lactate production and histone lactylation
Additionally, side effects include diarrhea, mild fever, trouble sleeping, headaches, and pain, itching, or swelling at the injection site
Phase 2 body composition substudy data using DEXA scans showed that retatrutide participants lost predominantly fat mass, with a favorable fat-to-lean mass loss ratio
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