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Both in vitro and in vivo studies have confirmed the protection of the alveolar epithelium from oxygen radical toxicity by treatment with NAC
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This finding was significant enough that the tirzepatide drug label now advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation
When levels are chronically low, the shift tends to be gradual rather than dramatic
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