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Although both are analogs of human GLP-1, there are a few molecular differences between these two agents that may be the reason that a hypersensitivity reaction occurred with liraglutide and not semaglutide

doi: 10.1007/s00125-023-05906-7 57 AdriaenssensAEBiggsEKDarwishTTadrossJSukthankarTGirishMet al

As GLP-1 receptor agonists, these peptide drugs mimic the incretin hormone GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appetite [9]

Without it, your metabolism slows slightly, your hunger increases significantly, and your body becomes remarkably efficient at storing calories as fat