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Pivonello, De M
However, scientists should consider copper metabolism when designing experimental protocols, especially for prolonged exposure or high concentrations
However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics
Published results from Eli Lilly showed that tirzepatide produced sustained weight loss throughout the full treatment period, with participants averaging a 22.9% decrease in body weight at the highest dose
