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Peptide 20 recognition Superimposition of the TMDs of GIPR, GLP-1R and GCGR bound by peptide 20 shows that the three receptors employed conserved residues in the lower half of the TMD pocket to recognize the well-overlapped peptide N-terminal region (residues 1 to 11), while the peptide C terminus engaged by ECL1, the N-terminal -helix of ECD and the extracellular tip of TM1 display receptor-specific positions and orientations (Fig