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They were also less likely to ovulate, since their response to hormones that trigger ovulationsuch as follicle-stimulating hormone (FSH)was blunted [ R , R ]

Histone modification analyses have documented GHK-Cu-associated changes in acetylation and methylation marks on histones H3 and H4, particularly at gene loci demonstrating altered transcriptional activity

Excess copper contributes to oxidative stress, inflammation, and potential toxicity, the opposite of what GHK-Cu is supposed to do. Researchers have generally found that GHK-Cu helps regulate copper rather than overload it, but the line between beneficial and harmful copper exposure depends on dose, tissue type, and individual biology

Jiang, S