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Evidence from obesity trials suggests that discontinuation of semaglutide may be followed by substantial weight regain and partial reversal of metabolic improvements ( 7.2 Weight loss is not the only body-composition outcome that matters Although preservation of lean mass is clinically important during GLP-1 receptor agonist therapy, the optimal strategy for monitoring and protecting muscle health in KOA populations remains uncertain
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This study was designed as a prospective, parallel-group, randomised trial
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