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CJC-1295 without DAC occupies the sweet spot: longer-acting than sermorelin (which degrades too fast for reliable clinical effect), shorter-acting than DAC (which sacrifices pulsatility), and considerably cheaper than tesamorelin (the only FDA-approved option in this class)

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Greibe et al

Furthermore, a prospective study involving PD patients on L-dopa therapy compared to other treatments showed that L-dopa therapy in PD patients was associated with a modest increase in plasma homocysteine level with a significant reduction in B12 serum level (OSuilleabhain et al