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Myeloid-derived suppressor cells (MDSCs) and activated tumor-associated macrophages express ARG1, which consumes arginine to form a microenvironment that is not conducive to T cells, resulting in tumor immunosuppression (Rodriguez et al., 2017

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Best for: Systemic applications or multiple injury sites where broad distribution is desired Option C: Separated Sessions Sequence: BPC-157 in morning, cryotherapy in evening (or vice versa) Rationale: Eliminates potential interaction effects by separating the modalities entirely

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