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The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM 5-TR) describes OUD as a pattern of opioid use leading to problems or distress, where at least two of the following occurring within a 12-month period: Taking larger amounts or taking drugs over a longer period than intended
During recent years, it has become evident that this process involves intermediate states in which cells acquire various degrees of plasticity and differentiation potential, which may have broad implications in regenerative medicine and organ repair (reviewed in ref
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The resulting peptide has a nearly identical 3D spatial arrangement of functional groups as the originalmaintaining target binding affinitybut is unrecognizable to proteases that cleave L-amino acid peptide bonds
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