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Following dichotomization of ALT responders based on a median 12.9% decrease from baseline, we found that ALT responders were younger in age and did not have severe diabetes compared with ALT non-responders

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Such an approach simplifies and standardizes HFpEF diagnosis, but it is not without controversy, garnering criticisms ranging from oversimplification of disease heterogeneity to misclassification particularly in patients with low H 2 FPEF score( 2 FPEF scoring algorithm has been validated in various patient cohorts( 2 FPEF scoring system may be adapted as a novel standard to assess the clinical applicability and translational value of various pre-clinical HFpEF models