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The brand cites approximately 1.5% annual collagen depletion starting in the 30s, per brand materials
This is manageable
Attributed to the selective IR paradox, compensatory hyperinsulinemia can amplify hyperandrogenism via several mechanisms: (i) cross-activation of insulin and/or IGF-1 receptors, which enhances LH-mediated expression of key steroidogenic enzymes (e.g., CYP17A1) in ovarian theca cells and increases androgen synthesis
So, its important to watch hydration, electrolytes, blood pressure, and kidney function, especially in the first months of treatment and after increasing the dose
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