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Most studies concerning the effects of IGF-1 derivatives have been carried out in non-human animal models or cell culture studies Insulin Like Growth Factor Receptor Interactions IGF-1 binds to at least two cell surface receptors: IGF-1R and the insulin receptor

Thyroid and cardiac concerns In phase 2 trials, 2-11% of patients receiving retatrutide experienced cardiac arrhythmias, compared with 2% in the placebo group

The first FDA-approved GLP-1 receptor agonist, exenatide, was introduced for type 2 diabetes in 2005 and required twice-daily injections

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