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Consistent with previous studies, cotadutide outperformed GLP-1 alone (40 nmol/kg/day liraglutide) in achieving maximal weight loss in obese mice, and this was attributed to the increased energy expenditure ( An alternative approach in the design of effective synthetic co-agonists has been to modify GLP-1 analogues to confer increased GCG activity
Semaglutide has been used for weight loss in clinical trials for up to Ozempic and Rybelsus are intended for long-term use in managing type 2 diabetes
It can also help identify patients' adherence and response to lifestyle changes required for sustained weight loss
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