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Anelli et al
Figure 6 2.6 PCD and the immune microenvironment of COPD As demonstrated by the various types of PCD described above, the remodeling of the immune microenvironment in COPD is not driven by a single mode of cell death, but rather the result of the superimposed effects of multiple PCDs across different cell types and disease stages: at the level of cell lineage, structural cells (airway/alveolar epithelium, vascular endothelium, smooth muscle, fibroblasts) primarily undergo apoptosis, necroptosis, ferroptosis, and cuproptosis, which together determine barrier integrity, the degree of airway remodeling, and the extent of alveolar destruction
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Furthermore, the literature related to the effects of RT on basal BDNF remain mixed and requires further investigation to clarify this relationship, with an emphasis on delineating these findings based on populations (i.e., young vs
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