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The STEP-4 trial (Rubino et al., JAMA , 2021) studied this directly: patients who reached goal weight on 2.4 mg were randomized to continue 2.4 mg vs switch to placebo
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doi: 10.1007/s40262-021-01025-x 28 KawaiTSunBYoshinoHFengDSuzukiYFukazawaMet al
Keep Accountability in Place A recent analysis presented at the 2025 American Diabetes Association conference found that patients who maintained monthly check-ins with their care team regained significantly less weight than those who stopped follow-up visits
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