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The stated rationale was safety concerns, though many clinicians and compounding pharmacy groups argued the agency overstepped, noting that no specific safety signal justified the restriction for most of the affected peptides
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Furthermore, NO interaction with hydrogen bonds to Ser-339, Trp-683, Val-65, Asp-601, and Hem-801 was demonstrated by rutin and IL-6, as well as by helix A and helix D
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