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PMID 20696856

The 2021 trial (PMID 34684429) explicitly concluded that supplementation beyond 35 days improved recovery and reduced fatigue across sex and age framing the five-week-plus window as where the effect is established rather than emerging

Longevity and maintenance The effects achieved may require continued treatment to maintain, and the discontinuation of treatment could result in a gradual return to normal skin tone

Women Drinks to Reach 0.08% 100 lbs ~1.5 standard drinks 120 lbs ~2 standard drinks 140 lbs ~3 standard drinks 160 lbs ~34 standard drinks 180 lbs ~4 standard drinks 200 lbs ~45 standard drinks Men Drinks to Reach 0.08% 140 lbs ~3 standard drinks 160 lbs ~34 standard drinks 180 lbs ~4 standard drinks 200 lbs ~45 standard drinks 220 lbs ~5 standard drinks 240 lbs ~56 standard drinks All estimates based on Widmark Formula at approximately 1 hour elapsed time