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After this initial breakdown, intrinsic factor is secreted into the stomach to bind with B-12 and help it absorb later in the intestines

When you have PA, special antibodies are preventing your body from making IF (intrinsic factor)

Hi juanpablo111 It is not uncommon for some symptoms to appear to get worse before they get better as the B12 you are having starts repairing the damage done to your nervous system and your brain starts getting multiple messages from part of the body it had "forgotten about" or lost contact with

Together with folate, cobalamins are essential cofactors required for DNA synthesis in cells where chromosomal replication and division are occurringmost notably the bone marrow and myeloid cells