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A downregulating variant slows its enzyme, which can cause its substrate (such as homocysteine or catecholamines) to build up
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Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease
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