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At high doses, RSV can inhibit cytochrome P450 (CYP3A4) enzymes (54), altering the metabolism of co-administered drugs and potentially leading to adverse effects
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In the case of GSTs, these multifunctional and essential enzymes are involved in many processes, such as detoxification, signaling, redox homeostasis, plant metabolism, growth regulation, and adaptation to biotic and abiotic stress ( Tobamovirus ( Geminivirus ( Tenuivirus ( A relatively low number of studies have focused on the importance of the glutathione cycle and glutathione-associated enzymes in plant cell responses, both compatible and incompatible, or their potential role in developing resistance to plant viruses
