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Description

Binding of RGD motif-containing ligand mimetic compounds to site I is mechanically coupled to tertiary changes in the A domain, involving inward movement of the N-terminal 1 helix toward the MIDAS, forcing reorganization of the loop between the C-terminal F strand and 7 helix, a one-turn displacement of helix 7 and a hybrid domain swing out 42

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Mechanism: gene expression modulation upregulating antioxidant enzymes (SOD, catalase), reducing oxidative damage to RPE and photoreceptors

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