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Neurotransmitter regulation The nausea response depends heavily on serotonin signaling
It activates melanocortin receptors MC1R and MC3R, suppressing NF-kappaB nuclear translocation and consequently reducing pro-inflammatory cytokine production including TNF-alpha, IL-6, and IL-1beta
The TGA recently reported reported that all strengths of Mounjaro (tirzepatide) will be limited until 31 August 2024 due to unexpected high demand
This precaution highlights the importance of thorough medical screening and personalized risk assessment before starting treatment
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