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These animals frequently display cardiac phenotypes, including hypertrophy, fibrosis and diastolic dysfunction ( 2.3.2 ob/ob mice (H 2 FPEF score 34) The leptin-deficient ob/ob mice develop obesity and type II diabetes secondary to hyperphagia, hyperglycemia and insulin resistance ( ob/ob mice display rapid weight gain within 2 weeks after birth and by 4 weeks of age, they develop marked hyperglycemia (Westman, 1968