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Clinical trials GLP-1 RAs are an antidiabetic class of drugs, but their effect on the relative reduction in HbA1c compared to placebo was moderate (0.41.2%) in the outcome trials
Insulin transport across the blood-brain barrier can occur independently of the insulin receptor
Characterized by insulin resistance, gradual progressive loss of insulin secretion by -cells, and being heavily driven by being overweight or obese [98], T2DM leads to hyperglycemia, excessive urine production, increased risk of cardiovascular disease, and changes in energy metabolism [106]
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