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10.1016/0028-3908(96)84626-0 34 GawrylukJ
Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem
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These act as antioxidants by helping eliminate free radicals that harm cells
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