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Rotate sites with every dose to prevent bruising, scar tissue, and irritation

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The calculators recommended split at 4 mg and above is every 3 days (q3d): each shot carries three-sevenths of the weekly dose across about 2.3 injections a week, which cuts the peak-to-trough swing to roughly 43% of the weekly swing

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2025 [cited 31 Dec 2025] Cyanocobalamin (intramuscular route)-Description and Brand Names - Mayo Clinic [Internet]

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