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Kinetic Analysis of [ 11 C]PIB Retention We used the flow-independent Washout Allometric Reference Method (WARM) for analysis of washout and binding of [ 11 C]PIB expressed as the tracers binding potential in brain (BP ND ) ( ND without linearization with the operational equation, where m and m ND are measured PET signals as time-activity curves in regions with displaceable binding, and in a reference region, respectively
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