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Effects of exenatide twice daily versus sitagliptin on 24-hour glucose, glucoregulatory, and hormonal measures: a randomized, double-blind, crossover study

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The Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study found that youth (aged 10 to 17 years) with T2DM experienced a 20% to 35% annual decline in -cell function, which is significantly higher than the ~7% decline seen in older individuals [43-45]