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doi: 10.1016/j.redox.2022.102380 16 NagataKKakizakiYYanagidaKAraiTNakanoKHamanoFet al

This was not observed with GLP-1 or GLP-1/GIP agonists and may be related to the glucagon component Higher discontinuation rates than semaglutide or tirzepatide, though some discontinuations were due to "perceived excessive weight loss" in patients with lower BMI The higher GI burden correlates with retatrutide's higher weight loss (28.7%) Orforglipron# Orforglipron is an oral non-peptide GLP-1 agonist

Nevertheless, the main populations of this study are Caucasian, Hispanic, and African-American