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Victoza (liraglutide), the first GLP-1 for type 2 diabetes to lose exclusivity in June 2024, may not generate significant savings due to its once-daily dosing and limited market share

5,19 Like any medication, GLP-1RAs may have side effects, including nausea, vomiting, diarrhea, and injection site reactions

Interestingly, GLP-1/exendin-4 administration in obese Zucker rats, which also develop insulin resistance, hyperinsulinemia and hyperlipidemia, reduces food intake and induced weight loss, which applies to lean rats, too

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