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The key milestones are as follows: The FDA granted orforglipron the Commissioner's National Priority Review Voucher, a designation that could compress the standard 10-12 month review period to as little as 1-2 months

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Less common but serious risks include: Pancreatitis Gallbladder disease Possible increased heart rate In rodent studies, GLP-1 receptor agonists showed thyroid C cell tumors

Additionally, the altered gastrointestinal motility may affect the timing of food delivery to the small intestine where natural enzymes from the pancreas act