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All dose ranges above are extrapolations from preclinical literature, not validated human clinical protocols
Encouragingly, PROTACs have shown therapeutic potential across a range of pathologies, including oncology, neurodegenerative diseases, inflammatory conditions, and viral infections, and may represent a transformative approach in the pursuit of efficacious PDE1B/10A-directed therapeutics for schizophrenia (Gustafson et al., 2015
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