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Sermorelin is older, more widely available, often less expensive, and has a long history of use
Early phase trials conducted in Croatia for inflammatory bowel disease reported safety with no toxicity, but detailed data never appeared in peer-reviewed literature
It contributes to the pathogenesis of arthritis not only by inducing pain, but also by increasing the production of catabolic molecules including proinflammatory cytokines, matrix metalloproteinases (MMP), and reactive oxygen species, which in turn contribute to articular tissue alterations
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