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28 Additionally, a 16-week trial of supplementation with GlyNAC (which boosts glutathione levels) in older adults improvedand in some cases reversedmultiple hallmarks of aging, including inflammation, mitochondrial dysfunction, and oxidative stress
To demonstrate the role of GSH in chemotherapy resistance, we analyzed transcriptomic data from chemotherapy patient samples in the GEO database and collected post-chemotherapy samples from patients who underwent neoadjuvant chemotherapy, assessing the expression levels of GSH and GSH synthesis-related antioxidant enzymes
J.FengL
Glutathione is given intravenously because this route delivers the antioxidant directly into the bloodstream, bypassing digestive breakdown that destroys nearly all of an oral dose
