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They cant
But the body guards its balance carefully
254 Although few genetic factors are known for ALS, multiple susceptibility variants exist in the major histocompatibility complex (MHC), especially in the human leukocyte antigen (HLA)
Furthermore, limited diagnostic capabilities, difficulty in identifying eligible patients, and variability in disease progression collectively contribute to low enrollment rates, prolonged study timelines, and compromised data integrity in rare disease trials, ultimately resulting in higher failure rates compared to non-rare disease trials 5,6
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