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Weeks 25-48: Maintenance Optimization Later treatment phases involve continued improvement at diminishing rates

These effects work together to combat muscle atrophy [41]

Through the 1990s and 2000s the GIP receptor was widely regarded as a poor drug target in metabolic disease, partly because GIP secretion is preserved or elevated in type 2 diabetes while its insulinotropic effect is blunted, and partly because GIP-receptor knockout animals were resistant to diet-induced obesity, which pointed the wrong way