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Individuals with a Body Mass Index (BMI) of 30 or higher (obese)
Succinate supplementation was a phenocopy of decreased KG in its ability to sensitize CCNE1-driven cells to DNA-damaging agents and was rescued by competing KG supplementation (Extended Data Fig
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For example, rates of nausea in incretin mimetic trials typically range from ~15% to 22% and discontinuation due to AEs range from ~3% to 8%
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