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Clinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis.*1-6 Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.* Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.7-9

Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells

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