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Rather than manipulating individual pathways in isolation, effective intervention will likely require coordinated, context-dependent modulation of chaperones, autophagy, UPS activity, and ER stress responses

These studies may imply either direct effects or indirect, emergent effects that may arise in a community context as observed in the case of therapeutic drugs (Garcia-Santamarina et al, 2024), or from mixture effects involving co-consumed foods or compounds

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