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Age-related changes post-40 stem from diminished cellular resilience and repair.[3][11] This resilience is tied to the body's ability to handle oxidative stress and maintain homeostasis, processes that falter as NAD+ levels wane

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A comprehensive review in Nature Reviews Disease Primers described B12 deficiency as a significant and underrecognized public health concern, particularly among older adults, individuals with gastrointestinal conditions, and those following plant-based diets (Green et al., Nat Rev Dis Primers , 2017)